摘要
Retromer and sorting nexins(SNXs)transport cargoes from endosomes to the trans-Golgi network or plasma membrane.Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses,including members of Coronaviridae,Flaviviridae and Retroviridae.Key components of retromer/SNXs,such as Vps35,Vps26,SNX5 and SNX27,can affect multiple steps of the viral life cycle,including facilitating the entry of viruses into cells,participating in viral replication,and promoting the assembly of virions.Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus,which will shed mechanistic insights into controlling virus infection.
基金
supported by grants from National Natural Science Foundation of China(81871663 and 82072270)
Undergraduate Science and Technology Innovation Plan of International Class of Clinical Medicine in Shandong First Medical University(ZYKC2019-016)
Academic promotion programme of Shandong First Medical University(2019LJ001)。
