对76例癫痫患者丙戊酸钠血药浓度监测结果的分析

Analysis of monitoring results of serum valproate concentration in 76 pat ients with epilepsy

目的:探讨癫痫患者的年龄、性别、单药或联合用药、药物剂型等因素对丙戊酸钠血药浓度的影响,为合理用药提供参考依据。方法:采用化学发光免疫法监测76例癫痫住院患者的丙戊酸钠浓度,收集其基本资料,利用统计学方法对数据进行统计与分析。结果:老年人组的丙戊酸钠血清浓度显著低于青年人组、中年人组,差异有统计学意义(P<0.05)。单药治疗组的丙戊酸钠血清浓度显著高于联合治疗组,差异有统计学意义(P<0.05)。男性组与女性组的丙戊酸钠血清浓度相比,差异无统计学意义(P>0.05)。普通片组与缓释片组的丙戊酸钠血清浓度相比,差异无统计学意义(P>0.05)。结论:影响丙戊酸钠血药浓度的因素较多(包括年龄、合并用药情况等),临床使用此药时应根据患者的具体情况采用个体化给药方案,以提高临床疗效、减少不良反应的发生。

Objective:To investigate the influence of age,gender,single drug or combination drug,drug dosage form and other factors on blood concentration of sodium valproate in patients with epilepsy,so as to provide reference for rational drug use.Methods:Chemiluminescence immunoassay was used to monitor the concentration of sodium valproate in 76 inpatients with epilepsy.The basic data were collected and analyzed by statistical method.Results:The serum concentration of sodium valproate in the elderly group was significantly lower than that in the young group and the middle-aged group,and the difference was statistically significant(P<0.05).The serum concentration of sodium valproate in monotherapy group was significantly higher than that in combination therapy group,and the difference was statistically significant(P<0.05).There was no s ignificant difference in the serum concentration of valproate b etween the male group and the female group(P>0.05).There was no significant difference in the s erum concentration of s odium valproate between the normal tablet group and the sustained release tablet group(P>0.05).Conclusions:There are many factors affecting the blood concentration of sodium valproate(including age,combined medication,etc.).Individualized administration regimen should be adopted according to the specific situation of patients in clinical use of this drug to improve clinical efficacy and reduce the occur rence of adverse reactions.