摘要
BACKGROUND Chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL) is often associated with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin.Coincidence of CLL/SLL and urothelial carcinoma(UC) is very rare.Herein,we report a case of synchronous renal pelvis carcinoma with SLL.CASE SUMMARY A 78-year-old man presented with the complaint of terminal painless gross hematuria for the past 2 mo.On physical examination,enlarged lymph nodes were palpable in the cervical and axillary regions.The patient’s peripheral blood film was normal.He had a significant smoking history for the past 50 years.Cystoscopy revealed bleeding in the left upper urinary tract.Abdominal computed tomography imaging demonstrated a left renal pelvis tumor.The patient underwent laparoscopic radical nephroureterectomy.Histopathology revealed left renal pelvis high-grade invasive papillary UC and SLL involving the kidney and bone marrow.Renal pelvis lymphatic tissue and lymphocytes were positive for CD5,CD20,and CD23.In addition,the following results were obtained:CD3(-),Ki-67(30%+),Bcl-2(+),Bcl-6(+),CD10(-),and CD79a(+).Moreover,no UC metastasis was observed in the lymph nodes.CONCLUSION This is the first case of coincident CLL/SLL and upper tract UC in the literature.Cancer patients with lymphadenopathies should always be investigated to rule out the possibility of synchronous or metachronous malignancy.
