摘要
Intestinal flora plays a key role in nutrient absorption,metabolism and immune defense,and is considered to be the cornerstone of maintaining the health of human hosts.Bile acids synthesized in the liver can not only promote the absorption of fat-soluble substances in the intestine,but also directly or indirectly affect the structure and function of intestinal flora.Under the action of intestinal flora,bile acids can be converted into secondary bile acids,which can be reabsorbed back to the liver through the enterohepatic circulation.The complex dialogue mechanism between intestinal flora and bile acids is involved in the development of intestinal inflammation such as inflammatory bowel disease(IBD).In this review,the effects of intestinal flora,bile acids and their interactions on IBD and the progress of treatment were reviewed.
基金
Supported by General Research of Xi’an Science and Technology Planning Project,No.2022JH-YBYJ-0265
Shaanxi Province Natural Science Basic Research Program-General Project,No.2019JM-580
Project of Shaanxi Administration of Traditional Chinese Medicine,No.2019-ZZ-JC010
Shaanxi Provincial Hospital of Traditional Chinese Medicine,No.2021-07 and No.2018-04。