慢性肾脏病与肌少症

Chronic kidney disease and sarcopenia

慢性肾脏病(chronic kidney disease,CKD)是以肾脏结构异常和功能逐渐丧失为特征的慢性疾病,增龄、共病、多重用药等是导致CKD高发的危险因素。CKD患者常并发多种疾病和老年综合征,肌少症就是其中之一,患者可表现为肌力下降、肌量减少以及肌肉生理功能减退,严重影响生活质量。随着CKD患者肾小球滤过率的下降,肌少症的发生率逐渐增高;而肌少症又会进一步增加CKD的不良预后。文章将结合相关文献,从临床角度出发,阐述CKD与肌少症的相互关联以及CKD合并肌少症的治疗。

Chronic kidney disease(CKD)is a chronic disease characterized by abnormal structure of kidney and the gradual loss of function.Aging,comorbidity and multiple drug use are the risk factors leading to high incidence of CKD.CKD patients are often complicated with a variety of diseases and geriatric syndromes,and sarcopenia is one of them.Patients present with decreased muscle strength,decreased muscle mass and decreased muscle physiological function,which seriously affect the quality of life.With the decrease of glomerular filtration rate in patients with CKD,the prevalence of sarcopenia gradually is increased.On the other hand,sarcopenia further increases the poor prognosis of CKD.In this paper,based on relevant literature and from the clinical perspective,the correlation between CKD and sarcopenia as well as the treatment for CKD with sarcopenia will be elaborated.