艾司西酞普兰联合右佐匹克隆治疗脑卒中后焦虑抑郁的疗效观察

Efficacy observation of escitalopram combined with eszopiclone in the treatment of anxiety and depression after stroke

目的分析脑卒中后焦虑抑郁特点、原因,总结艾司西酞普兰+右佐匹克隆治疗的有效性。方法80例脑卒中后焦虑抑郁患者,依据随机数字表法分为对照组及观察组,每组40例。对照组采取艾司西酞普兰治疗,观察组采用艾司西酞普兰联合右佐匹克隆治疗。比较两组患者的治疗效果、不良反应发生情况、负性情绪与睡眠质量评分。结果观察组患者的治疗总有效率97.50%高于对照组的85.00%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组焦虑自评量表(SAS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)评分比较,差异无统计学意义(P>0.05);治疗8周后,两组SAS、SDS、PSQI评分均低于本组治疗前,且观察组SAS评分(37.60±3.40)分、SDS评分(36.60±3.30)分、PSQI评分(6.10±1.02)分均低于对照组的(46.50±4.30)、(45.50±4.30)、(11.20±1.20)分,差异具有统计学意义(P<0.05)。结论艾司西酞普兰+右佐匹克隆治疗脑卒中后焦虑抑郁患者的效果显著,能促进患者负性情绪、睡眠质量改善,安全性理想。

Objective To analyze the characteristics and causes of anxiety and depression after stroke,and summarize the effectiveness of escitalopram combined with eszopiclone therapy.Methods A total of 80 patients with anxiety and depression after stroke were divided into control group and observation group according to random numerical table,with 40 cases in each group.The control group was treated with escitalopram,and the observation group was treated with escitalopram combined with eszopiclone.The therapeutic effects,occurrence of adverse reactions,negative emotions and sleep quality score were compared between the two groups.Results The total effective rate 97.50%of the observation group was higher than 85.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of incidence of adverse reactions between the two groups(P>0.05).Before treatment,there was no statistically significant difference in the scores of Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS)and Pittsburgh Sleep Quality Index(PSQI)between the two groups(P>0.05).After 8 weeks of treatment,the SAS,SDS and PSQI scores of the two groups were lower than those of this group before treatment;In the observation group,the SAS score was(37.60±3.40)points,the SDS score was(36.60±3.30)points,and the PSQI score was(6.10±1.02)points,which were lower than(46.50±4.30),(45.50±4.30)and(11.20±1.20)points in the control group;the differences were all statistically significant(P<0.05).Conclusion Escitalopram combined with eszopiclone has significant effect in the treatment of patients with anxiety and depression after stroke,which can promote the improvement of negative emotions and sleep quality in patients with ideal safety.