艾司西酞普兰治疗老年抑郁症的效果研究

Study on the effect of escitalopram in the treatment of senile depression

目的 研究老年抑郁症患者应用艾司西酞普兰治疗的效果。方法 86例老年抑郁症患者,依照治疗方案的差异分为对照组与实验组,各43例。对照组患者应用帕罗西汀治疗方案,实验组患者应用艾司西酞普兰治疗方案。比较两组患者临床疗效及治疗前后汉密尔顿抑郁量表(HAMD)评分。结果 两组总有效率对比差异无统计学意义(P>0.05)。对照组治疗后2、4、8周HAMD评分分别为(19.03±4.24)、(14.24±4.19)、(8.55±3.02)分,实验组治疗后2、4、8周HAMD评分分别为(16.09±4.15)、(11.02±4.03)、(8.27±2.98)分。治疗后2、4、8周,两组HAMD评分均明显低于本组治疗前,差异具有统计学意义(P<0.05);治疗后2、4周,实验组HAMD评分低于对照组,差异有统计学意义(P<0.05);治疗后8周,两组HAMD评分对比差异无统计学意义(P>0.05)。结论 老年抑郁症患者应用帕罗西汀及艾司西酞普兰均可取得一定的疗效,但是艾司西酞普兰能够缩短患者抑郁症状改善时间。

Objective To study the effect of escitalopram in the treatment of senile depression.Methods A total of 86 senile patients with depression were divided into control group and experimental group according to the difference of treatment regimens,with 43 cases in each group.Patients in the control group were treated with paroxetine,and patients in the experimental group were treated with escitalopram.The clinical efficacy and Hamilton depression scale(HAMD)scores before and after treatment were compared between the two groups.Results There was no statistically significant difference in the total effective rate between the two groups(P>0.05).The HAMD scores of the control group were(19.03±4.24),(14.24±4.19),and(8.55±3.02)points at 2,4,and 8 weeks after treatment, and the HAMD scores of the experimental group were (16.09±4.15), (11.02±4.03), and (8.27±2.98) points at 2, 4, and 8 weeks after treatment. At 2, 4, and 8 weeks after treatment, the HAMD scores of the two groups were significantly lower than those of this group before treatment, and the difference was statistically significant (P<0.05). At 2 and 4 weeks after treatment, the HAMD scores of the experimental group was lower than those of the control group, and the difference was statistically significant (P<0.05). At 8 weeks after treatment, there was no statistically significant difference in HAMD scores between the two groups (P>0.05). Conclusion The application of paroxetine and escitalopram can achieve a certain effect in senile depression patients, but escitalopram can shorten the improvement time of patients' depressive symptoms.