中性粒细胞外陷阱在风湿性疾病中的研究进展

Research progress of neutrophil extracellular traps in rheumatic diseases

风湿性疾病是一种影响组织和关节的炎症性疾病, 其特征为严重的免疫失调。中性粒细胞是免疫失调的关键因素, 在风湿性疾病中起重要作用。中性粒细胞外陷阱(NETs)是中性粒细胞受刺激时释放的网状结构, 其作为一种新型的免疫防御机制引起了广泛关注。现就NETs的形成、功能及其在风湿性疾病和其他疾病中的作用进行综述。

Rheumatic diseases are inflammatory diseases characterized by severe immune dysregulation,which can affect tissues and joints.Neutrophils are the key factor contributing to immune disorders,and they play an important role in rheumatic diseases.Neutrophil extracellular traps(NETs)are network structures released by neutrophil granulocytes when stimulated.As a novel immune defense mechanism,NETs have attracted wide attention.In this paper,the formation,function and role of NETs in rheumatic diseases and other diseases were reviewed.