子宫内膜异位症患者凝血功能变化及其临床意义

Changes of coagulation function in patients with endometriosis and its clinical significance

目的分析子宫内膜异位症患者的凝血功能变化情况及其临床意义。方法选取本院收治的子宫内膜异位症患者60例为研究组,选取同期明确诊断的良性卵欒囊肿患者60例为对照组,观察两组患者的凝血指标,比较子宫内膜异位症不同囊肿大小患者的凝血指标,比较子宫内膜异位症单双侧惠者的凝血指标。结果研究组的凝血酶时间(TT)、凝血酶原时间(PT)分别为(10.39±3.54)、(10.29±1.11)s,均显著低于对照组的(16.05±485)、(1532±295)s;血小板总数(PLT)、纤维蛋白原(FIB)、D-二聚体(D-D)分别为(279.32±26.84)×10^(9)/L、(4.11±0.32)g/L、(0.98士0.37)mg/L.均显著高于对照组的(243.66±25.45)×10^(9)/L、(3.31±1.01)g/L、(0.59±0.20)mg/L,差异有统计学意义(P<0.05);两组的活化部分凝血活酶时间(APTT)比较,差异无统计学意义(P>0.05)。囊肿≤5 cm患者的APTT、FIB显著低于囊肿>5 cm者,PT、PLT显著高于囊肿>5 cm者,差异有统计学意义(P<0.05);二者的TT、D-D比较,差异无统计学意义(P>0.05)。双侧和单侧子宫内膜异位症患者的各项凝血指标及血小板总数比较,差异无统计学意义(P>0.05)。结论凝血功能和dt小板检查可能为临床子宫内膜舁位症的预测提供有利依据,为后续的特殊生物标志物研究提供参考和借鉴。

Obeetive To analyze the changes of coagulation function in patients with endometriosis and its clinical significance.Methods 60 patients with endomtriosis admitted in our hospial were slected as the study group,and 60 patients with benign ovarian cyst diagnosed in the same period were sclected as the control gtoup.The coagulation indexes of the two groups of patients were observed,and the coagulation indexes of endometriosis patients with different cyst sizes were compared,and the coagulation indexes of endometriosis patients with unilateral and bilateral were compared.Results The thrombin time(TT)and prothrombin time(PT)of the study group were were(10.39±3.54)s and(10.29±1.11)s,respectively,sigifcantly shorter than(16.05±4.85)、(15.32±2.95)s of the control group,and the total platelet count(PLT),fibrinogen(FIB)and D dimer(D-D)of the observation group were(279.32±26.84)×10^(9)/L,(4.11±0.32)g/L and(0.98±0.37)mg/L,respectively,significantly higher than(243.66±25.45)×10^(9)/L、(3.31±1.01)g/L、(0.59±0.20)mg/L of the control group,and the difereces were satistically significant(P<0.05);there was no significant difference in activated partial thromboplastin time(APTT)between the two groups.APTT and FIDB of patients with cyst≤5 cm were significantly lower than those with cyst>5 cm,PT and PLT were significantly higher than those with cyst>5 cm,and the dflerences were stistically sigificant(P<0.05);there were no significant diferences in TT and D-D between the two types(P>0.05).There were no sigificant differences in the blood coagulation indexes and the total number of platelets between bilateral and unilateral endometriosis patients(P>0.05).Conclusion The examination of blood coagulation function and platelet may provide a favorable basis for the prediction of clinical endometriosis,and provide a reference for the subsequent study of special biomarkers.