梅毒感染孕产妇梅毒母婴阻断的干预措施及效果探讨

Intervention measures and effects of mother-to-child syphilis blocking in pregnant women with syphilis infection

目的探究梅毒感染孕产妇梅毒母婴阻断的干预方法及临床疗效。方法回顾性分析本院收治的梅毒孕产妇60例的临床资料,将未接受梅毒母婴阻断的12例纳入对照组,将接受梅毒母婴阻断干预的48例纳入研究组,对两组孕产妇的妊娠结局及新生儿出生后的身体状况进行比较。结果对照组的出生率为25.00%,明显低于研究组的100%,对照组的人工终止妊娠率、稽留流产率、死胎率分别为50.00%、16.67%、&33%,研究组未出现不良妊娠结局,差异有统计学意义(P<0.05)。对照组的健康足月胎儿占比33.33%,明显低于研究组的91.68%,对照组的低出生体重儿、出生缺陷儿占比均高于研究组,差异有统计学意义(P<0.05);两组的早产儿占比比较,差异无统计学意义(P>0.05)。结论为确保孕妇能够持续妊娠,应早期进行梅毒血清学检测,确定其是否存在梅毒感染并及时对感染者进行母婴阻断干预,以减少不良妊娠结局及新生儿不良身体状况的发生。

Objective To explore the intervention method and clinical effect of mother-to-child syphilis blocking in pregnant women with syphilis infection.Methods The clinical data of 60 cases of pregnant women with syphilis admitted to our hospital were retrospectively analyzed.12 cases without mother-to-child transmission of syphilis were enrolled in the control group,and 48 cases with mother-to-child transmission of syphilis were enrolled in the study group.The pregnancy outcomes and neonatal physical status were compared between the two groups.Results The birth rate of the control group was 25.00%,which was significantly lower than 100%of the study group;the artificial termination rate,missed abortion rate and stillbirth rate of the control group were 50.00%,16.67%and 8.33%,while there were no adverse pregnancy outcomes in the study group,and the differences were statistically significant(P<0.05).The proportion of health full-term fetuses in the control group was 33.33%,which was significantly lower than 91.68%in the study group;the proportion of low birth weight infants and birth defects in the control group were higher than those in the study group,and the differences were statistically significant(P<0.05);there was no significant difference in the proportion of preterm infants between the two groups(P>0.05).Conclusion In order to ensure that pregnant women can continue pregnancy,early syphilis serological testing should be carried out to determine whether there is syphilis infection in pregnant women,and timely mother-to-child blocking intervention should be carried out to reduce the incidence of adverse pregnancy outcomes and adverse physical conditions of newborns.