加味褚氏安胎方联合常规治疗对肾虚血瘀型血栓前状态致复发性流产患者的临床疗效

Clinical effects of Supplemented CHU’s Antai Decoction combined with conventional treatment on patients with recurrent miscarriage in prethrombotic state due to Kidney Deficiency and Blood Stasis

目的 探讨加味褚氏安胎方联合常规治疗对肾虚血瘀型血栓前状态致复发性流产患者的临床疗效。方法 90例患者随机分为对照组和观察组,每组45例,对照组给予常规治疗(地屈孕酮、阿司匹林),观察组在对照组基础上加用加味褚氏安胎方,疗程4周。检测临床疗效、中医证候评分、凝血-纤溶指标(APTT、PT、TT、FIB、D-D、PS、PC)、孕12周胚胎存活率、不良反应发生率变化。结果 观察组总有效率、孕12周胚胎存活率高于对照组(P<0.05),不良反应发生率更低(P<0.05)。治疗后,2组中医证候评分、FIB、D-D降低(P<0.05),PS、PC升高(P<0.05),APTT、TT延长(P<0.05),PT缩短(P<0.05),以观察组更明显(P<0.05)。结论 加味褚氏安胎方联合常规治疗可安全有效地改善肾虚血瘀型血栓前状态致复发性流产患者血栓前状态,缓解临床症状,提高胚胎存活率。

AIM To explore the clinical effects of Supplemented CHU’s Antai Decoction combined with conventional treatment on patients with recurrent miscarriage in prethrombotic state due to Kidney Deficiency and Blood Stasis Pattern.METHODS Ninety patients were randomly assigned into control group(45 cases) for 4-week intervention of conventional treatment(didroxyprogesterone, aspirin), and observation group(45 cases) for 4-week intervention of both Supplemented CHU’s Antai Decoction and conventional treatment. The changes in clinical efficacy, TCM syndrome scores, coagulation-fibrinolysis indices(APTT, PT, TT, FIB, D-D, PS, PC), survival rate of embryos at 12-week pregnancy and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate and survival rate of embryos at 12-week pregnancy than the control group(P<0.05), along with lower incidence of adverse reactions(P<0.05). After the treatment, the two groups displayed decreased TCM syndrome scores, FIB and D-D(P<0.05), increased PS and PC, prolonged APTT and TT(P<0.05), and shortened PT(P<0.05), especially for the observation group(P<0.05).CONCLUSION For the patients with recurrent miscarriage in prethrombotic state due to Kidney Deficiency and Blood Stasis, Supplemented CHU’s Antai Decoction combined with conventional treatment can safely and effectively improve prethrombotic state, relieve clinical symptoms, and improve the survival rate of embryos.