金天格胶囊联合阿法骨化醇对四肢骨折患者的临床疗效

Clinical effects of Jintiange Capsules combined with alfacalcidol on patients with limb fractures

目的 探讨金天格胶囊联合阿法骨化醇对四肢骨折患者的临床疗效。方法 96例患者随机分为对照组(47例)和观察组(49例),均行手术复位,对照组给予阿法骨化醇,观察组在对照组基础上加用金天格胶囊,疗程8周。检测2组临床疗效、骨折愈合进程指标(骨痂生长评分、骨折愈合时间)、骨再生相关因子(TGF-β1、BMP-2、VEGF)、骨代谢指标(BALP、BGP、TRACP-5b、CTX-Ⅰ)、并发症发生率变化。结果 观察组总有效率高于对照组(P<0.05),骨折愈合时间更短(P<0.05),并发症发生率更低(P<0.05)。治疗后,2组骨痂生长评分、骨再生相关因子、BALP、BGP升高(P<0.05),TRACP-5b、CTX-Ⅰ降低(P<0.05),以观察组更明显(P<0.05)。结论 金天格胶囊联合阿法骨化醇可安全有效地提高四肢骨折患者TGF-β1、BMP-2、VEGF水平,有利于骨再生,从而可促进骨折愈合进程。

AIM To explore the clinical effects of Jintiange Capsules combined with alfacalcidol on patients with limb fractures.METHODS Ninety-six patients underwent surgical reduction were randomly assigned into control group(47 cases) for 8-week administration of alfacalcidol, and observation group(49 cases) for 8-week administration of both Jintiange Capsules and alfacalcidol. The changes in clinical efficacy, fracture healing process indices(callus growth scores, fracture healing time), bone regeneration-related factors(TGF-β1, BMP-2, VEGF), bone metabolism indices(BALP, BGP, TRACP-5 b, CTX-Ⅰ) and incidence of complications were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05), along with shorter fracture healing time(P<0.05) and lower incidence of complications(P<0.05). After the treatment, the two groups displayed increased callus growth score, bone regeneration-related factors, BALP and BGP(P<0.05), and decreased TRACP-5 b and CTX-Ⅰ(P<0.05), especially for the observation group(P<0.05).CONCLUSION For the patients with limb fractures, Jintiange Capsules combined with alfacalcidol can safely and effectively enhance TGF-β1, BMP-2 and VEGF levels, and help to bone regeneration, thus promote fracture healing process.