胆道^(125)I粒子条支架治疗恶性梗阻性黄疸的临床研究

Clinical study of biliary ^(125)I seed strips stent in treating malignant obstructive jaundice

目的研究使用胆道^(125)I粒子条支架和普通金属支架治疗恶性梗阻性黄疸(MOJ)的疗效差异。方法回顾性分析2016年1月至2019年12月在淮南市第一人民医院介入放射科治疗的30例恶性梗阻性黄疸病人的临床资料,其中粒子组为使用^(125)I粒子条支架治疗的15例,普通组为使用普通金属支架治疗15例。根据肝功能及胆道肿瘤标记物等指标评价近期疗效,生存时间评价远期疗效。结果粒子组及普通组均可显著降低肝功能指标,粒子组同时可显著降低胆道肿瘤标记物指标。此外,粒子组中位生存时间及平均生存时间[(207.00±41.22)d,(210.19±35.74)d]均长于普通组[(90.00±41.12)d,(81.77±17.93)d],差异有统计学意义(P<0.05)。结论胆道^(125)I粒子条支架治疗恶性梗阻性黄疸可以显著提高病人生存时间。

Objective To investigate the difference in the efficacy of biliary ^(125)I seed strips stent and common metal stent in treating malignant obstructive jaundice(MOJ).Methods The clinical data of 30 malignant obstructive jaundice patients treated in the Depart-ment of Interventional Radiology,Huainan First People's Hospital from January 2016 to December 2019 were retrospectively analyzed.Among them,the particle group was 15 cases treated with ^(125)I seed strips stent,the common group was treated with common metal stent in 15 cases.The short-term curative effect,survival time and long-term curative effect were evaluated according to liver function and biliary tumor markers.Results The indices of liver function were significantly decreased in both the particle group and the common group.Meanwhile,the biliary tumor marker in the particle group was significantly reduced.Additionally,the median survival time and the mean survival time in the particle group were(207.00±41.22)days and(210.19±35.74)days respectively,both of which were longer than those in the common group[(90.00±41.12)days and(81.77±17.93)days]respectively,the difference between the two groups were statistically significant(P<0.05).Conclusion The treatment of malignant obstructive jaundice by biliary ^(125)I seed strips stent can sig-nificantly improve the survival time of patients.