急性缺血性脑卒中临床应用阿替普酶溶栓疗法的预后效益

Prognostic benefit of clinical application of alteplase thrombolytic therapy in acute ischemic stroke

目的:急性缺血性脑卒中临床应用阿替普酶溶栓疗法的预后效益分析。方法:以本院于2019年1月至2020年12月收治的80例急性缺血性脑卒中患者为研究病例,基于随机动态数字表以及40例单组区间标准划分为对照组、观察组;对照组开展常规疗法,观察组基于对照组开展阿替普酶溶栓疗法;分析两组患者治疗前后的神经功能、炎症因子水平、脑血流动力学指标。结果:治疗前,两组患者的NIHSS评分以及炎症因子水平、脑血流动力学指标均无明显差异(P>0.05);治疗后观察组的NIHSS评分与炎症因子方面所得数据均低于对照组(P<0.05),且观察组治疗后的大脑后动脉收缩期最大血流速度(Vs)、平均血流速度(Vm)均高于对照组(P<0.05),阻力指数(RI)低于对照组(P<0.05)。结论:急性缺血性脑卒中患者接受阿替普酶溶栓疗法有利于更好的消除炎症因子,改善患者的脑血流动力学指标,对其神经功能有一定的积极作用。

Objective:To analyze the prognostic benefit of clinical application of alteplase thrombolytic therapy in acute ischemic stroke.Methods:80 patients with acute ischemic stroke admitted in our hospital between January 2019 and December 2020 were used as the study cases.Based on the random dynamic number table and the standard of 40 single-group intervals,they were divided into the control group and the observation group.The control group carried out conventional therapy,and the observation group carried out alteplase thrombolytic therapy based on the control group;the nerve function,inflammatory factor levels,and cerebral hemodynamic indexes of the two groups of patients before and after treatment were analyzed.Results:Before treatment,there was no significant difference in NIHSS scores,inflammatory factor levels,and cerebral hemodynamic indicators between the two groups of patients(P>0.05);after treatment,the NIHSS scores and inflammatory factors of the observation group were lower than the control group(P<0.05),and the maximum blood flow velocity(Vs)and average blood flow velocity(Vm)of the posterior cerebral artery in the observation group after treatment were higher than those of the control group(P<0.05),and the resistance index(RI)was lower Control group(P<0.05).Conclusion:Alteplase thrombolytic therapy in patients with acute ischemic stroke is beneficial to better eliminate inflammatory factors,improve the cerebral hemodynamic indicators of patients,and have a certain positive effect on its neurological function.