摘要
目的对比CT引导下氩氦刀冷冻消融与微波消融治疗原发性肝细胞癌(pHCC)近期疗效及对患者免疫功能的影响。方法回顾性分析52例原发性pHCC患者,其中24例接受CT引导下氩氦刀冷冻消融(冷冻组)、28例接受CT引导下微波消融(微波组),比较2组消融后1个月疗效,分析组间及组内消融前1日与消融后4周外周血CD4^(+)、CD8^(+)T淋巴细胞占比及CD4^(+)/CD8^(+)的差异。结果消融后1个月,冷冻组客观缓解率(87.50%)与微波组(85.71%)差异无统计学意义(P=0.833)。消融前1日,组间外周血CD4^(+)、CD8^(+)T淋巴细胞占比及CD4^(+)/CD8^(+)差异均无统计学意义(P均>0.05);消融后4周,组间外周血CD4^(+)、CD8^(+)T淋巴细胞占比及CD4^(+)/CD8^(+)差异均有统计学意义(P均<0.05),外周血CD4^(+)T淋巴细胞占比及CD4^(+)/CD8^(+)均较消融前1日升高(P均<0.001)、CD8^(+)T淋巴细胞占比较消融前1日降低(P均<0.001)。结论氩氦刀冷冻消融与微波消融治疗pHCC近期疗效确切且相当,前者增强免疫功能的效果更佳。
Objective To compare the short-term effect of argon-helium cryoablation and microwave ablation under the guidance of CT for primary hepatocellular carcinoma(pHCC)and impact on patients'immune function.Methods A total of 52 patients with pHCC were retrospectively analyzed,including 24 cases underwent CT-guided argon-helium cryoablation(cryoablation group)and 28 underwent CT-guided microwave ablation(microwave group).The therapeutic effects were compared between groups 1 month after ablation,the proportion of CD4^(+)T lymphocytes,CD8^(+)T lymphocytes and CD4^(+)/CD8^(+)in peripheral blood were also compared between groups and within group 1 day before and 4 weeks after ablation.Results One month after ablation,there was no significant difference of the objective remission rate between cryoablation group(87.50%)and microwave group(85.71%,P=0.833).There was no significant difference of the percentage of CD4^(+)T lymphocytes,CD8^(+)T lymphocytes nor CD4^(+)/CD8^(+)between groups 1 day before ablation(all P>0.05),while significant differences of the proportion of CD4^(+)T lymphocytes,CD8^(+)T lymphocytes and CD4^(+)/CD8^(+)were found in both groups 4 weeks after ablation(all P<0.05).Four weeks after ablation,the percentage of CD4^(+)T lymphocytes and CD4^(+)/CD8^(+)in peripheral blood of all patients were higher than those 1 day before ablation(all P<0.001),while the percentage of CD8^(+)T lymphocytes were lower than those 1 day before ablation(both P<0.001).Conclusion Both argon-helium cryoablation and microwave ablation had exact and similar short-term efficacy for treating pHCC,and the former had better effect on improving patients'immune function.
作者
谭业栋
张永涛
张立成
刘宏云
孙文俏
胡效坤
TAN Yedong;ZHANG Yongtao;ZHANG Licheng;LIU Hongyun;SUN Wenqiao;HU Xiaokun(Interventional Medical Center,West Coast Hospital Affiliated to Qingdao University,Qingdao 266000,China;Department of Minimally Invasive Intervention of Oncology,Weihai Municipal Hospital Affiliated to Shandong University,Weihai 264200,China)
出处
《中国介入影像与治疗学》
北大核心
2022年第10期609-613,共5页
Chinese Journal of Interventional Imaging and Therapy
基金
国家重点研发计划项目(2019YFE0120100)
中国医药教育协会重大科学攻关问题和医药技术难题科研课题(2020KTZ003)。
关键词
癌
肝细胞
介入治疗
氩氦刀冷冻消融
微波消融
carcinoma,hepatocellular
interventional therapy
argon-helium cryoablation
microwave ablation