摘要
Dear Editor,Hepatitis B virus(HBV)is a hepatotropic virus that can establish a persistent and chronic infection in humans.Chronic hepatitis B(CHB)infection is associated with an increased risk of hepatic decompensation,cirrhosis,and hepatocellular carcinoma.1 Emerging studies show that lactate,an end product of anaerobic glycolysis,has an important role in metabolism beyond energy production and is also a regulator of the tumor microenvironment(TME)and immune cell function.2 It is noteworthy that lactate levels have been associated with mortality in patients,and large HBV surface proteins(LHBs)have been shown to reduce Pyruvate kinase M2(PKM2)activity and thereby increase overall glucose consumption and lactate production in hepatocytes.
