摘要
年龄相关性黄斑变性(AMD)已被认为是最严重的眼科疾病之一。遗传、老化、氧化应激和炎症等在AMD发生发展中起着重要作用,而且Rho激酶在很多细胞周期过程中发挥着重要作用,Rho/ROCK通路的异常激活参与了AMD的发病过程。本文对Rho/ROCK信号通路的结构、活化、功能、调控AMD的病理机制以及靶向Rho/ROCK通路治疗AMD的潜力进行综述。
Age-related macular degeneration(AMD)has been recognized as one of the most severe eye diseases.Heredity,aging,oxidative stress and inflammation play essential roles in the development of AMD.It has been found that Rho-associated kinase(ROCK)plays an important role in many cell cycle processes,and abnormal activation of the Rho/ROCK pathway is involved in the pathogenesis of AMD.This article reviews the structure,activation,function,and regulation on AMD of the Rho/ROCK signaling pathway,and the potential of targeting Rho/ROCK signaling pathway in treating AMD.
作者
李宝花
郭承伟
LI Baohua;GUO Chengwei(The First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong Province,China)
出处
《眼科新进展》
CAS
北大核心
2022年第10期837-840,共4页
Recent Advances in Ophthalmology
基金
中医药循证能力建设项目(编号:2019XZZX-YK009)
山东省中医药科技发展计划项目(编号:2019-0086)。
