头针联合体针对帕金森病运动症状的治疗效应:随机临床研究

Effect of combined scalp and body acupuncture on Parkinson’s disease:A randomized clinical trial

Objective:To observe the therapeutic effect of combined scalp and body acupuncture on the motor symptoms in Parkinson’s disease(PD),and on the score of levodopa equivalent dose(LED).Methods:This is a randomized,single blind trial.Sixty-six patients with PD were randomized into an acupuncture+medication group(33 patients)and a medication group(33 patients).The patients were aware of allocation and the assessors were blinded to group assignment and therapeutic regimen.AntiPD drugs were administered in both groups.In the acupuncture+medication group,scalp and body acupuncture therapy was added.Treatments were applied for 8 weeks.In scalp acupuncture,the anterior oblique line of the vertex-temporal(MS6),lateral line 1 of the vertex(MS8),lateral line 2 of the vertex(MS9),and lower-lateral line of the occiput(MS14)were selected.In the body acupuncture,the acupoints included Bǎihuì(百会GV20),Sìshéncōng(四神聪EX-HN1),and Dàzhuī(大椎GV14),as well as the bilateral Fēngchí(风池GB20),Nèiguān(内关PC6),Hégǔ(合谷LI4),Gānshū(肝俞BL18),Shènshū(肾俞BL23),Yánglíngquán(阳陵泉GB34),Zúsānlǐ(足三里ST36),Fēnglóng(丰隆ST40),Sānyīnjiāo(三阴交SP6),Tàixī(太溪KI3),and Tàichōng(太冲LR3).Before and after treatments,the unified Parkinson’s disease rating scale(UPDRS),3section of the UPDRS(UPDRS-Ⅲ),and motor dysfunction rating scale for Parkinson’s disease(MDRSPD)were scored in the patients.The therapeutic effect of traditional Chinese medicine(TCM)and LED score were compared between both groups.Results:Thirty-three cases were included in data analysis in each group.After treatment,UPDRS scores were(28.77±8.85)and(36.58±10.16)points,UPDRS-Ⅲscores were(12.16±1.97)and(17.47±2.93)points and MDRSPD scores were(15.56±3.31)and(19.13±4.87)points in the acupuncture+medication and medication groups respectively.The UPDRS,UPDRS-Ⅲ,and MDRSPD scores all reduced after treatments in both groups(all P<0.05).All three scores were lower in the acupuncture+medication group than in the medication group(all P<0.05).When examining the therapeutic effects of TCM,the total effective rate was 87.88%in the acupuncture+medication group and 75.76%in the medication group(P<0.05).After treatment,the LED scores were(387.55±146.24)points and(437.42±183.16)points in the acupuncture+medication and medication groups,respectively.The LED dose differences before and after treatment for the acupuncture+medication and medication groups were(40.36±16.33)points and(95.88±35.79)points,respectively.The LED scores in both groups were higher than the pre-treatment scores(P<0.05).However,the post-treatment LED score was lower in the acupuncture+medication group than in the medication group(P<0.05),as was the dose difference before and after treatment(P<0.05).No relevant adverse reaction was found in each group.Conclusion:In addition to anti-PD medication,the scalp and body acupuncture may effectively relieve the motor symptoms of PD and improve the control of LED score.