膳食宏量营养素与多发性硬化的两样本孟德尔随机化因果研究

Causal relationships between dietary macronutrients and multiple sclerosis:A two-sample Mendelian randomization study

目的探索膳食宏量营养素与多发性硬化(multiple sclerosis,MS)风险的因果关系。方法从社会科学遗传学联盟(Social Science Genetic Association Consortium,SSGAC)数据中提取出20条全基因组显著(P<5×10^(-8))的膳食宏量营养素的单糖核苷酸多态性(single nucleotide polymorphisms,SNPs)位点,并在国际多发性硬化遗传学联盟(International MS Genetics Consortium,IMSGC)数据中匹配了该20条SNPs的结局数据,采用加权中位数、逆方差加权法、MR-Egger法进行两样本孟德尔随机化分析。结果加权中位数法结果显示,膳食碳水化合物由遗传决定的一个标准差的升高使多发性硬化的发病风险降低67%(OR=0.33,95%CI:0.13~0.85)。蛋白质和脂肪与多发性硬化的关联无统计学意义(P>0.05)。结论膳食碳水化合物的相对摄入量增加会降低多发性硬化的风险。

Objective To explore the causal relationship between dietary macronutrients and the risk of multiple sclerosis(MS).Methods Twenty genome-wide significant(P<5×10^(-8))single nucleotide polymorphisms for dietary macronutrients were extracted from the Social Science Genetic Association Consortium(SSGAC).And their association with MS risk were investigated in the International MS Genetics Consortium(IMSGC).The two-sample MR methods included weighted median estimator,inverse variance weighted and MR-Egger.Results The weighted median estimator method showed that increased relative carbohydrates intake(per 1 standard deviation)causally decreased the MS risk by 67%(OR=0.33,95%CI:0.13~0.85).There was no statistical significance between relative protein and relative fat intake with MS risk(P>0.05).Conclusion The higher relative intake of dietary carbohydrates are associated with a reduced risk of MS.