首发抑郁症伴自杀意念患者大脑功能连接时间动力学改变

Temporal dynamics changes of brain functional connectivity in first-episode depression patients with suicidal ideation

目的观察伴自杀意念(SI)首发抑郁症患者大脑功能连接(FC)的时间动力学改变。方法前瞻性纳入57例首发抑郁症伴SI患者(SI组)、42例首发抑郁症不伴SI患者(NSI组)及48名健康志愿者(HC组),行脑功能MRI和抑郁症相关量表评估;根据FC密度(FCD)标准差量化整个大脑、大脑半球间及半球内动态FCD(dFCD)的时间变异性,分析FC时间动力学改变。结果SI组汉密尔顿抑郁量表24项(HAMD-24)总分大于NSI组(P<0.05)。SI组左侧颞中回的全脑dFCD方差值高于NSI组和HC组(P均<0.05),SI组右侧颞中回半球内dFCD方差值高于HC组(P<0.05),而SI组和NSI组右侧额中回/额下回半球间dFCD方差值均低于HC组(P均<0.05)。结论首发抑郁症伴SI患者额、颞叶FC存在动态改变。

Objective To observe the temporal dynamics changes of brain functional connectivity(FC)in first-episode depression patients with suicidal ideation(SI).Methods A total of 57 first-episode depression patients with SI(SI group),42 first-episode depression patients without SI(NSI group)and 48 healthy volunteers(HC group)were prospectively enrolled.Brain functional MRI and depression related scale evaluation were performed,the time variability of global,inter-and intra-hemispheric dynamic FC density(dFCD)were quantified based on the standard deviation of FC density(FCD),and the temporal dynamics changes of brain FC were analyzed.Results The total score of Hamilton depression scale 24-items(HAMD-24)of SI group was higher than that of NSI group(P<0.05).The global dFCD variance of left middle temporal gyrus in SI group was higher than that in NSI group and HC group(both P<0.05),of right middle temporal gyrus in SI group was higher than that in HC group(P<0.05).The intra-hemispheric dFCD variance of right middle temporal gyrus/inferior frontal gyrus in SI group and NSI group were lower than those in HC group(both P<0.05).Conclusion FC of frontal and temporal lobes dynamicly changed in first-episode depression patients with SI.