川崎病及川崎病冠状动脉病变患儿肠道菌群变化

The change of intestinal flora in Kawasaki disease children and Kawasaki children with coronary artery lesions

目的 研究川崎病及川崎病冠状动脉病变患儿肠道菌群变化情况,为调节其肠道菌群提供参考。方法 选择我院2018年7月至2020年5月纳入的97例川崎病患儿作为观察对象,依据超声心动图检查将其中出现冠状动脉病变的45例患儿作为研究组,另外52例单纯川崎病患儿作为对照组,检测两组患儿肠道菌群情况。结果 两组患儿肠道菌群多样性相比差异无统计学意义(P>0.05),但研究组患儿肠道菌群丰度高于对照组(P<0.05)。研究组患儿肠道厚壁菌门占35.85%,低于对照组的54.06%(P<0.05)。研究组患儿肠道拟杆菌门占33.57%,高于对照组的21.30%(P<0.05)。研究组患儿肠道变形菌门占24.39%,与对照组的25.21%相比差异无统计学意义(P>0.05)。研究组患儿肠道乳杆菌属、拟杆菌属、韦荣球菌属分别占3.87%、25.03%、2.75%,与对照组的21.23%、16.23%、17.95%相比差异均有统计学意义(均P<0.05)。结论 川崎病冠状动脉病变患儿肠道菌群状况与单纯川崎病患儿存在显著差异,合并冠状动脉病变的患儿肠道菌群紊乱更为显著,应受到临床重视。

Objective To observe the intestinal flora change in Kawasaki disease(KD) children and Kawasaki children with coronary artery lesions(KD-CAL), providing a reference for the treatment. Methods A total of 97 KD children treated in our hospital from July 2018 to May 2020 were chosen as the subjects. According to ultrasonic cardiogram results, 45 KD-CAL children were included in the observation group, 52 KD children were included in the control group. Intestinal flora conditions were measured and analyzed. Results There were no significant differences between two groups in intestinal flora population(all P>0.05), but the intestinal flora abundance in the observation group was higher than that in control group(P<0.05). The occurrence of intestinal Firmicutes in the observation group(35.85%) was lower than that in control group(54.06%)(P<0.05). The incidence of intestinal Bacteroidetes in the observation group(33.57%) was higher than that in control group(21.30%)(P<0.05). The incidences of intestinal Proteobacteria in the observation group(24.39%) and control group(25.21%) were not significantly different(P>0.05). The incidences of intestinal Lactobacillus, Bacteroides and Veillonella in the observation group(3.87%, 25.03%, 2.75%) were significantly lower than those in control group(21.23%, 16.23%, 17.95%)(all P<0.05). Conclusion There are significant differences between KD children and KD-CAL children in intestinal flora. The intestinal flora disturbance is more obvious in children with KD-CAL, which should be primarily concerned in clinical treatment.