妊娠期妇女甲状腺功能异常与其营养指标、血脂变化及QT间期的相关性

Correlation between the abnormal thyroid function of pregnant women and their nutrition status,blood lipid level change,and QT interval

目的:研究妊娠期妇女甲状腺功能异常与营养指标、血脂变化及QT间期的相关性.方法:以2020年1月-2021年12月本院诊治的妊娠期甲状腺功能异常孕妇188例,其中甲状腺功能亢进(甲亢组)98例、功能减低(甲减组)90例,同期产前检查健康孕妇50例为对照组,比较血清甲状腺功能指标、营养、血脂变化及QT间期差异.分析妊娠期甲状腺功能异常与营养、血脂变化及QT间期的相关性.结果:甲亢组、甲减组、对照组血清三碘甲状腺氨酸(T_(3))、四碘甲状腺氨酸(T_(4))、促甲状腺激素(TSH)水平有差异,总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总蛋白(TP)、白蛋白(ALB)水平及QT间期(336.68±12.72ms、370.25±22.72ms、368.04±22.26ms)存在差异(均P=0.000).相关性分析,妊娠期甲状腺功能异常患者血清T_(3)、T_(4)、TSH水平与TC、HDL、LDL、TP、ALB、QT均具有相关性(均P=0.000).结论:妊娠期妇女甲状腺功能异常与其营养指标、血脂变化及QT间期均呈显著相关性.

Objective: To study the correlation between the abnormal thyroid function of pregnant women and their nutrition status,blood lipid level change,and QT interval.Methods:A total of 188 pregnant women with abnormal thyroid function who had been diagnosed and treated were included in this study from January 2020 to December 2020,which included 98 women with hyperthyroidism in group A and 90 women with hypothyroidism in group B.50 health pregnant women were selected in group C during the same period.The levels of thyroid function indexes,the nutrition status,the blood lipid levels changes,and the QT interval of the women were compared among the three groups.The correlation between the abnormal thyroid function of the women and their nutrition status,blood lipid level change,and QT interval was analyzed.Results:There were significant differences in the serum levels of triiodothyronine(T_(3)),tetraiodothyronine(T_(4)),thyroid stimulating hormone(TSH),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL),total protein(TP),and albumin(ALB),and the QT interval(336.68±12.72 ms vs.370.25±22.72 ms vs.368.04±22.26 ms)of the women among the three groups(all P=0.000).Correlation analysis showed that the levels of serum T_(3),T_(4) and TSH of the pregnant women with abnormal thyroid function were correlated with their levels of TC,HDL,LDL,TP,and ALB,and their QT interval(all P=0.000).Conclusion:The abnormal thyroid function during pregnancy of the women is significantly correlated with their nutrition indexes,blood lipid level change,and QT interval.