摘要
无膜细胞器是缺乏分隔膜的细胞区室。无膜细胞器在多个生物学过程中发挥着关键作用,包括基因转录、RNA代谢、翻译、蛋白质修饰和信号转导等。细胞在受到外界刺激时,会产生应激反应,维持细胞稳态。而由液–液相分离(Liquid-liquid phase separation)驱动而形成的无膜细胞器具有类液体特性,可以快速响应压力,在细胞应激反应中发挥重要作用。本文以应激颗粒、P–小体、核仁和卡哈尔体为无膜细胞器代表,总结了无膜细胞器与应激反应的关系,以及无膜细胞器与疾病的联系。
Membraneless organelles are cellular compartments that lack a separating membrane. Membraneless organelles play critical roles in multiple biological processes, including gene transcription, RNA metabolism,translation, protein modification, signal transduction, and so on. When the cells are stimulated, they initiate a series of stress responses to maintain homeostasis. Membraneless organelles formed by liquid-liquid phase separation have liquid-like properties, can rapidly respond to stress and play an important role in cellular stress responses. In this paper, we chose stress granules, P-bodies, nucleolus and Cajal bodies as representatives of membraneless organelles, and summarized the relationships between membraneless organelles and stress responses, and its links of membraneless organelles to disease.
作者
江天晴
邓诣群
文继开
JIANG Tianqing;DENG Yiqun;WEN Jikai(College of Life Sciences,South China Agricultural University/Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms,Guangzhou 510642,China)
出处
《华南农业大学学报》
CAS
CSCD
北大核心
2022年第6期136-147,共12页
Journal of South China Agricultural University
基金
国家自然科学基金-广东省联合基金(U1901207)
广东省教育厅重大基础研究项目(2018KZDXM015)
关键词
无膜细胞器
应激反应
稳态
相分离
Membraneless organelle
Stress response
Homeostasis
Phase separation