Nanozyme-Triggered Cascade Reactions from Cup-Shaped Nanomotors Promote Active Cellular Targeting

Self-propelled nanomotors have shown enormous potential in biomedical applications.Herein,we report on a nanozymepowered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under nearinfrared(NIR)laser irradiation.The nanomotor is constructed by the asymmetric decoration of platinum nanoparticles(PtNPs)at the bottom of gold nanocups(GNCs).PtNPs with robust peroxidase-(POD-)like activity are employed not only as propelling elements for nanomotors but also as continuous O_(2)generators to promote photodynamic therapy via catalyzing endogenous H_(2)O_(2)decomposition.Owing to the Janus structure,asymmetric propulsion force is generated to trigger the shortranged directional diffusion,facilitating broader diffusion areas and more efficient cellular searching and uptake.This cascade strategy combines key capabilities,i.e.,endogenous substrate-based self-propulsion,active cellular targeting,and enhanced dual-modal therapy,in one multifunctional nanomotor,which is crucial in advancing self-propelled nanomotors towards eventual therapeutic agents.