皮脂腺癌八例临床及病理分析

Sebaceous carcinoma:clinicopathological analysis and literature review of 8 cases

回顾性分析我院2017年5月至2022年4月诊断的8例皮脂腺癌临床病理资料,其中男3例,女5例,发病年龄平均72岁,临床表现为单个无痛性肿块,病程2个月~3年。6例位于眼睑,1例在面部,1例在耳后,8例患者中2例复发,均在眼睑部位。镜下见肿瘤细胞巢排列成不规则的小叶或结节状。胞质较少的嗜碱性基底样细胞,略呈栅栏状排列,主要位于周边,中央为胞质空亮的皮脂腺细胞。免疫组化CK、EMA、p63、AR阳性,Ki-67阳性率约20%~90%。

The data of eight cases with sebaceous carcinoma from May 2017 to April 2022 were analyzed retrospectively.The results showed 6 tumors were on the eyelid,one on the face,one on the opisthotic skin.The patients were 3 males and 5 females with a median age of 72 years.The clinical feature was a single painless mass and the course of disease ranged from 2 months to 3 years.Recurrence occurred in 2 of the 8 patients,and the recurrent skin lesions were located on the eyelid.Histological examination showed the tumor cells infiltrated in irregular lobules or nodules pattern.Sebaceous gland-like cells with empty cytoplasm were surrounded by the basal-like cells at the periphery of cellular nests.All of the cases were positive for CK,EMA,p63 and AR and had a high Ki-67 index(20%~90%).