血尿酸水平在出血转化发生机制中的作用研究进展

Research progress on the role of serum uric acid level in the pathogenesis of hemorrhagic transformation

血尿酸在机体内具有抗氧化和促氧化的双重生理特性。出血转化是急性缺血性脑卒中常见的并发症,其发生严重影响患者的预后。出血转化的发生与氧化应激、病理性炎症反应、血脑屏障破坏及阿替普酶溶栓等密切相关。大量研究表明,血尿酸通过多种途径影响了出血转化的发生与发展。文章对近年相关研究进行综述,为出血转化的防治提供参考。

Serum uric acid plays dual role in physiological conditions. Hemorrhagic transformation(HT) is a common complication of acute ischemic stroke, which deteriorates the prognosis of ischemic stroke. The pathogenesis of hemorrhagic transformation is closely related to oxidative stress, inflammatory cascade, destruction of blood-brain barrier and alteplase thrombolysis. Many previous studies have shown that serum uric acid affects the occurrence and development of hemorrhagic transformation through a variety of ways. The aim of this article is to systematically review relevant research to improve the prognosis of hemorrhagic transformation.