儿童急性淋巴细胞白血病预后相关因素的研究进展

Research progress on prognostic factors of childhood acute lymphoblastic leukemia

在过去的几十年中,儿童急性淋巴细胞白血病(ALL)在治疗方面取得了实质性的进展,目前的长期无事件生存率接近80%,但仍有多达20%的患儿复发。复发性ALL是儿童血液肿瘤相关死亡率的重要原因。因此,提高对儿童ALL的相关预后因素的认识非常重要。本文通过对临床特征、分子生物学因素、治疗相关因素、基因多态性这4个方面的预后因素作一系统综述,希望加强对其理解,在临床实践中能够实施更精确的风险分层和制定个性化的治疗计划。

Over the past few decades,substantial advances have been made in the treatment of childhood acute lymphoblastic leukemia(ALL),with the current long-term event-free survival rate approaching 80%,but up to 20%of children still have relapses.Recurrent ALL is an important cause of blood tumor-related mortality in children.Therefore,it is important to improve the understanding of the related prognostic factors of childhood ALL.In this paper,four prognostic factors including clinical characteristics,molecular biological factors,treatment-related factors and gene polymorphism were systematically reviewed,in the hope of enhancing their understanding,implementing more accurate risk stratification and developing personalized treatment plans in clinical practice.