摘要
血管衰老是心脑血管疾病的早期病理生理表现,与心、脑、肾及外周血管疾病等慢性病的发生发展密切相关。钠-葡萄糖共转运蛋白2(SGLT2)抑制剂是一种新型的降糖药,具有明确的心血管和肾脏保护作用。本文通过总结SGLT2抑制剂在血管衰老中的作用及相关机制,进一步了解SGLT2抑制剂对血管衰老的保护作用,以期为将来研究血管衰老及血管衰老相关疾病的干预提供新的思路。
Vascular aging is an early pathophysiological manifestation of cardiovascular and cerebrovascular diseases,which is closely related to the occurrence and development of chronic diseases such as heart,brain,kidney and peripheral vascular diseases.Sodium glucose cotransporter 2(SGLT2)inhibitor is a new type of hypoglycemic drug with clear cardiovascular and renal protective effects.This review summarizes the roles and mechanisms of SGLT2 inhibitors in vascular aging,which reveals the protective effect of SGLT2 inhibitors on vascular aging,as well as provides new ideas for future research on vascular aging and intervention of vascular aging related diseases.
作者
廖英宏
庄晓婷
白越
宋春莉
Liao Yinghong;Zhuang Xiaoting;Bai Yue;Song Chunli(Department of Cardiology,the Second Hospital of Jilin University,Changchun 130000,China)
出处
《国际内分泌代谢杂志》
2022年第5期373-376,共4页
International Journal of Endocrinology and Metabolism
基金
吉林省新型冠脉支架技术科技创新中心(20190902017TC)。
