光催化NAD(P)H再生的研究进展

Recent Advances on the Photocatalytic Regeneration of NAD(P)H

辅酶与酶催化反应紧密相关,是酶催化氧化还原反应过程中不可缺失的重要组成,其中,烟酰胺类辅酶NAD和NADP参与了大多数的酶催化氧化还原反应,是辅酶中最重要的一类.然而,辅酶的高成本限制了其实际应用.因此,烟酰胺辅酶的高效和低成本再生具有特别重要的意义.我们总结了还原型烟酰胺辅酶光催化再生方法的相关研究进展以及各种光敏剂的优缺点,提出了光催化NAD(P)H再生仍需要解决的问题.

Coenzymes play the roles of redox reagents in enzymatic reactions and are indispensable important components of the biochemical process.Among them,nicotinamide coenzymes(i.e.NAD and NADP)participate in most enzymatic redox reactions and are the most important types of coenzymes.However,the high price of coenzymes limits their practical applications.Therefore,the efficient and economical regeneration of nicotinamide coenzymes is of particular significance for industrial applications.In this review,the works on the photochemical protocols applied for the regeneration of reduced nicotinamide coenzymes(NAD(P)H)were summarized and the advantages and drawbacks of each protocol were figuredout.The problems that still need to be solved in photocatalytic regeneration of NAD(P)H are proposed.