高原地区房颤患者管理与达比加群抗凝治疗的疗效观察

Management of patients with atrial fibrillation at high altitude and efficacy of dabigatran anticoagulant therapy

目的:研究分析达比加群抗凝治疗高原地区房颤的临床价值。方法:随机选取2019年6月至2020年6月在日喀则市人民医院心内科接受治疗的高原地区房颤患者90例作为本次研究对象,随机分为两组,分别是对照组和观察组,每组45例。对照组患者为拒绝抗凝治疗接受常规传统治疗;观察组在传统治疗的基础上给予达比加群抗凝治疗。观察对比两组的患者治疗后的情况。结果:观察组患者的凝血酶时间TT、部分凝血酶原时间APTT、凝血酶原时间PT以及INR指标更佳;观察组患者的肝肾功能血肌酐CR、尿素氮BUN、甘油三酯以及转氨酶指标更低;观察组患者的不良反应发生率明显更低。结论:达比加群抗凝治疗高原地区房颤的疗效十分显著,有效调节凝血指标,降低肝肾功能的损伤,明显减少不良事件的发生风险,是一种非常安全有效的治疗方式,具有很高的临床价值,值得推广。

Objective:To study and analyze the clinical value of Dabi plus group anticoagulation in the treatment of AF in plateau area.Methods:90 patients with AF in plateau area who were treated in the Department of Cardiology of Rikaze people's Hospital from june2019 to june2020 were randomly selected as the subjects of this study.They were randomly divided into two groups,namely the control group and the observation group,45 cases in each group.The patients in the two groups were compared after treatment.Results:the thrombin time TT,APTT,Pt and INR of the observation group were better than those of the control group,and the difference between the two groups;The Cr,bun,triglyceride and transaminase in the patients with liver and kidney function in the observation group were lower than those in the control group.Conclusion:the curative effect of Dabi plus group anticoagulation on AF in plateau area is very significant,not only the anticoagulant effect is good,but also the coagulation index is effectively adjusted,the damage of liver and kidney function is obviously reduced,the occurrence of adverse events is reduced,and the safety is high,which is worth further promotion.