内皮细胞特异性分子-1在急性呼吸窘迫综合征中的作用研究进展

Research progress on the role of endothelial cell-specific molecular-1 in acute respiratory distress syndrome

急性呼吸窘迫综合征(ARDS)是一种多因素导致的常见呼吸系统危重症之一, 病死率高。ARDS具有高度异质性, 这可能是其缺乏高特异性、高敏感度的生物学指标的原因。因此, 探寻ARDS相关生物标志物并进行表型分析及建立风险分层模型, 对疾病诊断、预后预测及指导治疗有重大意义。内皮细胞特异性分子-1(ESM-1, 也称endocan)是一种内皮细胞分泌的可溶性硫酸皮肤素蛋白聚糖, 主要参与调控细胞增殖、分化及迁移等生物学行为。已有大量研究证实, ESM-1与炎症反应、内皮激活及功能障碍密切相关, 但在ARDS中是如何发挥作用的尚不完全清楚。本文就ESM-1的生物学特性及其成为ARDS相关临床生物标志物的潜在价值予以系统性综述, 以期为ARDS的早期预后评估及预防控制等临床应用提供科学依据。

Acute respiratory distress syndrome(ARDS),a common respiratory critical illness with multiple causes,is associated with high mortality.The high degree of heterogeneity may be the reason why it is lack of highly specific and sensitive biological biomarkers.Therefore,it is an urgent need to explore biomarkers,perform phenotypic analysis and establish risk stratification model for diagnosis,prognosis,and treatment of ARDS.Endothelial cells specificity molecular-1(ESM-1,endocan),is a soluble dermatan sulfate proteoglycan,and be involved in regulating biological behaviors such as cell proliferation,differentiation and migration.Numerous studies have confirmed that ESM-1 is closely related to inflammation,endothelial activation and dysfunction.However,the role of ESM-1 in the initiating and developing process of ARDS is still unclear.To provide a scientific basis for its clinical applications in ARDS,such as early prognosis assessment and timely prevent strategies,this paper focuses on the biological properties and the clinical value of ESM-1 as a potential biomarker for ARDS.