浅谈三碘甲状腺原氨酸对心脏的作用

The effect of triiodothyronine on the heart: A brief review

心肌和血管内皮组织中存在甲状腺激素受体, 对循环中甲状腺激素(TH)水平变化非常敏感, 尤其是三碘甲状腺原氨酸(T3), 即使发生细微变化都会对心血管系统产生不利影响。近年来的多项研究证据支持心血管事件发生时甲状腺功能异常与随后的不良心血管结局之间存在关联。一些临床试验发现亚临床甲状腺疾病的治疗可改善心血管危险因素, 这意味着TH治疗在减少心血管结局事件中的潜在益处。本文综述了T3与心血管疾病关系及其对心脏的生理作用, 以及T3在心脏衰竭和急性心肌梗死方面的治疗潜能。

Thyroid hormone receptors are expressed in myocardium and vascular endothelial tissue and are very sensitive to changes in circulating thyroid hormone(TH)levels,especially triiodothyronine(T3),therefore small changes can adversely affect the cardiovascular system.Evidence from several studies in recent years supports the association between abnormal thyroid function at the time of cardiovascular event and subsequent adverse cardiovascular outcomes.Several clinical trials have found that treatment of subclinical thyroid disease improves cardiovascular risk factors,suggesting the potential benefit of TH therapy in reducing cardiovascular outcome events.This article reviews the relationship between T3 and cardiovascular disease and its physiological effects on the heart,as well as the therapeutic potential of T3 in heart failure and acute myocardial infarction.