肠道菌群在肠-肾轴中对草酸钙结石形成影响的研究进展

Research progress about the effect of gut microbiome on the formation process of calcium oxalate stone through gut-kidney axis

草酸钙结石是肾结石的主要类型,其形成与草酸和钙的代谢密切相关。肠道菌群是定居在人类肠道内的正常菌群,对机体内多种代谢具有重要的调节作用。既往认为肠道菌群中产甲酸草酸杆菌是草酸钙结石形成的保护因素,但近年来发现,调节机体草酸代谢的细菌不仅限于产甲酸草酸杆菌。草酸钙结石患者具有与健康人群不同的肠道菌群,其通过肠-肾轴调节草酸在机体内的代谢,影响草酸钙肾结石的形成。本文阐述草酸钙结石患者肠道菌群特点,总结肠道菌群在草酸钙结石形成中的潜在功能及未来可能的临床应用。

Calcium oxalate(CaOx)stone is the main type,and its formation is closely related to the metabolism of oxalic acid and calcium.Gut Microbiome is normal microflora which settled in the human intestinal tract and plays an important role in regulating a variety of metabolism in the body.In the past,Oxalobacter formigenes in gut was a protective factor for the formation of CaOx stones.Recently,it has been found that the bacteria regulating oxalate metabolism were not limited to Oxalobacter formigenes.Gut Microbiome of CaOx stones formers is different from healthy people.It regulates the metabolism of oxalic acid in the body through the gut-kidney axis and affect the formation of CaOx stone.The purpose of this study is to describe the characteristics of intestinal flora in patients with CaOx stones,and to summarize its potential function in the formation of CaOx stones and its possible clinical application in the future.