急性脑梗死患者溶栓治疗后血管再闭塞的影响因素分析

Analysis of Influencing Factors of Vascular Reocclusion After Thrombolytic Therapy in Patients with Acute Cerebral Infarction

目的分析急性脑梗死患者溶栓治疗后血管再闭塞的影响因素。方法回顾性分析2019年12月至2020年12月在我院行静脉溶栓治疗的82例急性脑梗死患者的临床资料,统计患者治疗3 d后的血管再闭塞发生情况,分析急性脑梗死患者溶栓治疗后发生血管再闭塞的相关影响因素。结果82例急性脑梗死患者经静脉溶栓治疗后发生血管再闭塞20例,发生率为24.39%。单因素和Logistic回归分析显示,合并糖尿病、入院时NIHSS评分高、发病到溶栓治疗时间长是急性脑梗死患者溶栓治疗后发生血管再闭塞的危险因素(OR>1,P<0.05)。结论脑梗死患者溶栓治疗后血管再闭塞与合并糖尿病、入院时NIHSS评分高、发病到溶栓治疗时间长等有关,临床可据此制定针对性干预方案,以减少溶栓治疗后再闭塞发生风险。

Objective To analyze the influencing factors of vascular reocclusion after thrombolytic therapy in patients with acute cerebral infarction.Methods The clinical data of 82 patients with acute cerebral infarction who received intravenous thrombolysis in our hospital from December 2019 to December 2020 were retrospectively analyzed.The incidence of vascular reocclusion at 3 days after treatment of patients was counted,and the related influencing factors for the occurrence of vascular reocclusion after thrombolytic therapy in patients with acute cerebral infarction were analyzed.Results Among 82 patients with acute cerebral infarction,vascular reocclusion occurred in 20 cases after intravenous thrombolysis,and the incidence rate was 24.39%.Univariate analysis and Logistic regression analysis showed that complication of diabetes mellitus,high NIHSS score at admission,and long duration from onset to thrombolytic therapy were risk factors for the occurrence of vascular reocclusion after thrombolytic therapy in patients with acute cerebral infarction(OR>1,P<0.05).Conclusions Vascular reocclusion after thrombolytic therapy in patients with cerebral infarction is related to complication of diabetes mellitus,high NIHSS score at admission,and long duration from onset to thrombolytic therapy.Based on this,targeted intervention programs can be formulated to reduce the occurrence risk of reocclusion after thrombolytic therapy.