肾上腺素能受体单核苷酸多态性与镇痛相关性的研究进展

Research progress on correlation between adrenergic receptor single nucleotide polymorphism and analgesic effect

个体间的疼痛反应和对镇痛药物的敏感性存在明显差异,遗传因素是产生这种差异的主要原因。随着受体单核苷酸多态性检测技术进入高通量测序时代,肾上腺素能受体单核苷酸多态性与疼痛和镇痛敏感性相关性研究逐渐深入。肾上腺素能受体是介导儿茶酚胺作用的组织受体,有9种不同的亚型,其中参与疼痛和镇痛敏感性的主要是α_(2A)、β_(1)和β_(2)受体。ADRα_(2A)基因rs1800544位点存在单核苷酸多样性,并且与右美托咪定镇静镇痛相关,ADRβ_(1)基因的rs1801252和rs1801253多态性与痛觉过敏和镇痛效果相关,ADRβ_(2)基因的第16位(Arg16Gly)和第27位(Gln27Glu)多态性可能与药物耐受和个体间分娩疼痛差异性有关。本文将从以上三种受体单核苷酸多态性对疼痛敏感性和镇痛的影响进行综述。

There are significant differences in pain response and sensitivity to analgesic drugs among individuals.With the development of high-throughput detection technology,the correlation between single nucleotide polymorphism of adrenergic receptor and pain,analgesic sensitivity has been gradually deepened.Adrenergic receptor is one of tissue receptor that mediates the effect of catecholamine,nine adrenergic receptor subtypes have been identified from several species.And α_(2A),β_(1) and β_(2) receptor are the important ones involved in pain and analgesic sensitivity.The single nucleotide polymorphism of ADα_(2A) at rs1800544 is related to dexmedetomidine sedation and analgesia.Polymorphisms of ADRβ_(1) gene at rs1801252 and rs1801253 are associated with hyperalgesia and analgesic effect.Polymorphisms at position 16(Arg16Gly)and 27(Gln27Glu)of ADRβ_(2) gene may be related to drug tolerance and differences in labor pain among individuals.This article reviews the effects of SNPs of these three receptors gene on pain sensitivity and analgesia.