慢性阻塞性肺疾病合并肺癌共同发病机制

The common pathogenesis of chronic obstructive pulmonary disease with lung cancer

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)和肺癌是目前世界范围内导致死亡的主要呼吸系统疾病,给社会带来了沉重的负担。COPD和肺癌的高共病率提示二者可能存在共同的发病机制。其中吸烟、职业暴露和空气污染是二者共同的危险因素。越来越多的证据显示,肺衰老、遗传易感性、表观遗传、端粒、慢性炎症、氧化应激和肺部微生态等是COPD和肺癌发生发展的共同通路。本文就COPD合并肺癌的主要危险因素及共同发病机制作一综述,以期为临床早期诊断及治疗策略提供参考。

Chronic obstructive pulmonary disease(COPD)and lung cancer are the major respiratory diseases leading to death worldwide and impose a heavy burden to the society.The high comorbidities of COPD and lung cancer suggest that there may share a common pathogenesis.Smoking,occupational exposure and air pollution are the common risk factors.Accumulating evidence suggest-ed that lung aging,genetic susceptibility,epigenetics,telomere,chronic inflammation,oxidative stress and lung microecology are the common pathways of COPD and lung cancer.This article reviews the main risk factors and common pathogenesis of COPD with lung cancer,in order to provide reference for clinical early diagnosis and treatment strategy.