全乙酰化表没食子儿茶素没食子酸酯的合成纯化及生物活性研究进展

Advances in Synthesis, Purification and Bioactivities of Total Acetylated Epigallocatechin Gallate

表没食子儿茶素没食子酸酯(epigallocatechin-3-gallate,EGCG)是茶叶中重要的儿茶素成分,具有广泛的生物活性,但稳定性差、脂溶性差、生物利用度低,难以深度开发利用。乙酰化修饰是改善EGCG局限性的有效手段。全乙酰化表没食子儿茶素没食子酸酯(total acetylated epigallocatechin gallate,AcEGCG)是EGCG的全乙酰化修饰产物,其脂溶性和稳定性显著升高,生物利用度也更高,且其抗紫外线、细胞损伤修复以及抗癌等功能均优于EGCG,在食品、医药及化工领域应用前景广泛。本文综述了近期国内外关于AcEGCG的合成纯化方法、理化性质及相关生物活性研究进展,以期为后续AcEGCG的研究及开发利用提供参考。

Epigallocatechin-3-gallate(EGCG), one of the important catechins in tea, is reported to have a variety of bioactivities. However, EGCG is not fully utilized due to its poor liposolubility and stability, as well as low bioavailability.Acetylation modification of EGCG is an effective method to improve these limitations. Total acetylated epigallocatechin gallate(AcEGCG) is the fully acetylated product of EGCG. Compared to EGCG, AcEGCG has higher liposolubility, stability and bioavailability. Moreover, its physiological functions, such as anti-ultraviolet, cell damage repair and anti-cancer functions,are better than those of EGCG, suggesting a wide range of application prospects in the fields of food, medicine and chemical industry. This review will summarize recent advances in the synthesis, purification, physicochemical properties and bioactivities of Ac EGCG, in order to provide a reference for further research, development and utilization of AcEGCG.