水飞蓟宾防治前列腺癌的研究进展

Research progress of silybin in the prevention and treatment of prostate cancer

前列腺癌(prostate cancer,PCa)是老年男性中最常见的恶性肿瘤之一。早期前列腺癌患者对去势治疗很敏感,但绝大多数病例会复发,转变为去势抵抗性前列腺癌。因此,需要探索新的治疗靶点和治疗方法。水飞蓟宾(silibinin,silybin,SB)是一种天然黄酮类化合物,对PCa具有良好的防治作用。研究发现,水飞蓟宾能够通过抑制PCa细胞的增殖、诱导其凋亡、抑制其细胞周期和血管生成以及调节信号通路和改善微环境来治疗PCa。对水飞蓟宾预防治疗PCa的作用机制研究较多,并且体现出了明显的优势。近年来,由于对水飞蓟宾衍生物的开发研究,大大加强了它的治疗效果,使其在临床上的应用越来越广泛。本文综述了其对PCa的作用机制,以期为水飞蓟宾治疗PCa的临床应用提供理论依据。

Prostate cancer(PCa)is one of the most common malignant tumors in elderly men.Patients with early PCa are very sensitive to castration treatment,but most cases will relapse and turn into castration resistant PCa.Therefore,it is necessary to explore new therapeutic targets and treatment.Silibinin is a natural flavonoid,which has a good preventive and therapeutic effect on PCa.The study found that silibinin can treat PCa by inhibiting the proliferation of PCa cells,inducing apoptosis,inhibiting cell cycle and angiogenesis,regulating signal pathway and improving microenvironment.There are many studies on the mechanism of silibinin in the prevention and treatment of PCa,and it shows obvious advantages.In recent years,due to the development and research of silibinin derivatives,its therapeutic effect has been greatly strengthened,making it more and more widely used in clinical practice.This paper reviews its mechanism of action on PCa,in order to provide a theoretical basis for the clinical application of silybin in the treatment of PCa.