柠檬醛抑菌特性及其缓释制剂研究进展

Research Progress on Antibacterial Properties and Sustained-release Preparation of Citral

随着环保理念的加强和可持续发展战略的实施推进,高效、低毒成为抑菌剂生产和使用的必然趋势。柠檬醛属于开链单萜类化合物,是山苍子、柠檬草等的次级代谢产物,对细菌、真菌、病毒等有很好的抑制作用,可以开发为天然植物源抑菌剂代替化学杀菌剂使用。然而柠檬醛具有不稳定,易挥发,光、热条件下易分解等缺点,这些缺点限制了柠檬醛的应用。缓释制剂能将被包埋的活性物质缓慢释放,同时对活性物质起到稳定和保护的作用。该文以柠檬醛为对象,围绕柠檬醛的抑菌活性、抑菌机理进行阐述,同时分析柠檬醛在应用上的不足,并对柠檬醛缓释制剂的种类和应用等进行归纳总结,为柠檬醛抑菌剂的开发和柠檬醛缓释制剂的应用提供参考。

High efficiency and low toxicity have become the inevitable trend in the production and use of bacteriostatic agents with the strengthening of the concept of environmental protection and the implementation of sustainable development strategy. Citral,an open-chain monoterpene compound,is the secondary metabolite of Litsea cubeba and lemongrass. It has a good inhibitory effect on bacteria,fungi and viruses,and can be developed as a natural plant antibacterial agent instead of chemical fungicide. However,citral is unstable,volatileand easily decomposed under light and heat conditions,which limits its application. Sustained-release preparations can slowly release the embedded active substance and stabilize and protect the active substance.Herein,the antibacterial activity and mechanism of citral were expounded,and the disadvantages of its applicationwere analyzed. Moreover,the types and applications of citral sustained-release preparations weresummarized,which may provide a theoretical basis for the development of bacteriostatic agent of citral and application of citral sustained-release preparations.