脑膜瘤组织FASN、EphA2表达与疾病进展的关系

The Relationship Between FASN and EphA2 Expressions in Cancer Tissues and Disease Progression in Patients with Meningioma

目的 研究脑膜瘤患者肿瘤组织中脂肪酸合成酶(FASN)、上皮细胞激酶(EphA2)表达与疾病进展的关系。方法 回顾70例脑膜瘤患者临床资料。所有患者均接受手术治疗,术后病理组织统一送实验室检测。比较肿瘤组织与病灶周边正常组织中FASN、EphA2的表达情况,分析FASN、EphA2表达与脑膜瘤临床分期、病理组织类型、淋巴结转移、术后疾病复发的关系。结果 脑膜瘤患者肿瘤组织中FASN、EphA2的表达阳性率均高于病灶周边正常组织(P<0.05)。不同临床分期脑膜瘤患者肿瘤组织中FASN、EphA2的表达阳性率存在显著差异,Ⅲ期患者肿瘤组织中FASN、EphA2的表达阳性率高于Ⅰ期、Ⅱ期患者(P<0.05);不同病理类型患者肿瘤组织中FASN、EphA2的表达阳性率无明显差异(P>0.05);发生淋巴结转移的患者肿瘤组织中FASN、EphA2表达阳性率高于未发生淋巴结转移的患者(P<0.05);术后出现复发的患者肿瘤组织中EphA2表达阳性率高于未复发患者(P<0.05),FASN表达阳性率与未复发患者相比,差异无统计学意义(P>0.05)。结论 脑膜瘤患者肿瘤组织中FASN、EphA2呈现高表达水平,患者临床分期、淋巴结转移均与FASN、EphA2表达相关,术后疾病复发情况与EphA2表达相关。

Objective To study the relationship between expressions of fatty acid synthase(FASN) and epithelial kinase A2(EphA2) in cancer tissues and disease progression in patients with meningioma.Methods A total of 70 patients with meningioma treated in the hospital were enrolled.All underwent surgical treatment,and pathological tissues were given laboratory tests after surgery.The expressions of FASN and EphA2 in cancer tissues and normal para-cancerous tissues were compared.The relationship between FASN,EphA2 and clinical staging,pathological classifications,lymph node metastasis,postoperative disease recurrence was analyzed.Results The positive expression rates of FASN and EphA2 in cancer tissues were higher than those in normal para-cancerous tissues(P0.05).The positive expression rates of FASN and EphA2 in patients with lymph node metastasis were higher than those without lymph node metastasis(P0.05).Conclusion The expression levels of FASN and EphA2 in cancer tissues are higher than those in normal tissues in meningioma patients.The clinical staging and lymph node metastasis are related to the expressions of FASN and EphA2.The postoperative disease recurrence is related to the expression of EphA2.