原发性开角型青光眼的系统性危险因素

Systemic risk factors in patients with primary open-angle glaucoma

眼压异常升高是原发性开角型青光眼最主要的危险因素。临床目前一直沿用以眼压为靶点的青光眼诊疗模式。近年来发现,循环血流、体质指数、颅内压、营养代谢、中医偏颇体质类型、某些系统性疾病等多种系统性危险因素可能与青光眼发生、发展和转归相关。纠正系统性危险因素能否延缓青光眼进展被日益关注,成为潜在的青光眼辅助诊疗靶点。本文对各类青光眼系统性危险因素进行介绍,倡导重视系统性危险因素,提出以系统危险因素评估和个性化眼体同治相结合的青光眼诊疗体系。(眼科,2022,31:325-329)

Abnormally high intraocular pressure is the most significant risk factor for primary open-angle glaucoma(POAG).The clinical model of glaucoma treatment using intraocular pressure as the target has long been used.Various systemic risk factors such as circulating factors,body mass index,intracranial pressure,nutritional metabolism,constiturion types as defined by traditichal Chinese medicine,and some systemic diseases have been found to be related to glaucoma onset,progression and regression,and are being tried to be applied as new therapeutic targets for optic nerve protection treatment of glaucoma.This manuscript aims to provide an overview,on systemic risk factors of POAG,to advocate glaucoma doctors to pay attention to systemic risk factors and to build a new glaucoma diagnosis and treatment system combining systemic risk factor assessment and personalized ocular and physical co-treatment.(Ophthalmol CHN,2022,31:325-329)