景深延长型人工晶状体Symfony ZXR00的视觉质量研究

Clinical study of an extended depth-of-focus intraocular lens Symfony ZXR00

目的评价Symfony ZXR00植入术后患者的视觉质量。设计前瞻性非随机对照研究。研究对象2021年6月至2022年1月于解放军总医院第六医学中心行白内障超声乳化摘除联合IOL植入术的患者42例(42眼),其中植入Symfony ZXR00 IOL者18例(18眼),单焦点IOL A1-UV 24例(24眼)。方法比较两组术后3个月视力、对比敏感度、离焦曲线,并对光学干扰现象、脱镜率和视物满意度进行调查和分析。主要指标视力(LogMar)、对比敏感度、离焦曲线、光学干扰现象、脱镜率和视物满意度。结果术后3个月,Symfony组的裸眼远视力(-0.04±0.08)、裸眼中视力(-0.03±0.08)、裸眼近视力(0.28±0.16)、矫正近视力(-0.03±0.05)、矫正远视力下的中视力(-0.04±0.07)、矫正远视力下的近视力(0.27±0.13)显著优于单焦点A1-UV组(0.03±0.10、0.32±0.09、0.39±0.17、-0.01±0.02、0.30±0.11、0.48±0.19),P均<0.05;矫正远视力差异无统计学意义。Symfony组在-2.50 D离焦时,视力仍大于0.3。与单焦点IOL相比,各个空间频率对比敏感度均无统计学差异。Symfony组无严重的光学干扰现象,脱镜率为77.8%,显著高于A1-UV组的0%(χ^(2)=28.000,P=0.000)。两组视远时的满意率无显著差异。Symfony组的视中、视近的满意率(100%、77.8%)显著高于A1-UV组(20.8%、0%),P均=0.000。结论Symfony ZXR00可提供良好的远、中视力以及功能性近视力;其对比敏感度无显著下降,接近单焦点IOL。(眼科,2022,31:355-359)

Objective To evaluate visual quality of patients implanted with the extended depth-of-focus IOL Symfony ZXR00 after cataract surgery.Design Prospective nonrandomized controlled comparative study.Participants The study included 42 patients(42 eyes)who had cataract phacoemulsification surgery in the Sixth Medical Center of Chinese PLA Gereral Hospital from June 2021 to January 2022,wherein Symfony ZXR00 IOLs were implanted in 18 cases(18 eyes),and single focus IOLs A1-UV in 24 cases(24 eyes).Methods Visual acuity(VA),defocus curves and contrast sensitivity(CS)were compared 3 months postoperatively between the two groups.Optical interference,spectacle independence and visual satisfaction were also investigated and analyzed.Main Outcome Measures VA(LogMar),CS,defocus curves,optical interference,spectacle independence and visual satisfaction.Results After 3 months,uncorrected distant VA(UDVA)(-0.04±0.08)、uncorrected intermediate VA(UIVA)(-0.03±0.08)、uncorrected near VA(UNVA)(0.28±0.16)、corrected near VA(CNVA)(-0.03±0.05)、distance-corrected intermediate VA(DCIVA)(-0.04±0.07)and distance-corrected near VA(DCNVA)(0.27±0.13)were better in the Symfony ZXR00 group than in the A1-UV group(0.03±0.10,0.32±0.09,0.39±0.17,-0.01±0.02,0.30±0.11,0.48±0.19),all P<0.05.CDVA was similar in the two groups.The Symfony ZXR00 still provided visual acuity greater than 0.3 for a defocus level of-2.50 D.Contrast sensitivity was similar in the two groups at any spatial frequency.The patients in the Symfony group had no serious optical interference,and the spectacle independence rate was 77.8%,which was significantly higher than 0%in the A1-UV group(χ^(2)=28.000,P=0.000).There was no significant difference in the satisfaction rate for distance vision between the two groups.The patient satisfaction rates for intermediate vision in the Symfony group was 100%,which was significantly higher than 20.8%in the A1-UV group(χ^(2)=26.022,P=0.000).For near vision,the satisfaction rates were 77.8%and 0%in the two groups,respectively(χ^(2)=28.000,P=0.000).Conclusion Symfony ZXR00 can provide excellent distance,intermediate and functional near visual acuity,with no significant decline in contrast sensitivity and close to monofocal IOL.(Ophthalmol CHN,2022,31:355-359)