新疆维吾尔自治区538例Behcet综合征临床特点分析

Clinical characteristics of 538 cases of Behcet's syndrome in Xinjiang Uygur Autonomous Region

目的总结新疆维吾尔自治区Behcet综合征(BS)的临床特点,进一步认识其临床特征及发病规律。设计回顾性病例系列。研究对象2005~2020年新疆维吾尔自治区人民医院BS患者538例。方法回顾患者的人口学与临床资料。主要指标年龄、性别、首发症状、眼部病变、治疗用药及并发症。结果538例BS患者中,男女比例为1:1.96,平均年龄(37.37±12.83)岁,平均病程(4.72±6.40)年,平均住院时长(13.44±8.70)天,首诊科室以风湿科较多(57.0%),口腔溃疡是最常见的首发症状(69.7%)和临床表现(94.1%),治疗中免疫抑制剂使用占76.4%,使用频率最高为沙利度胺,口服糖皮质激素占37.7%,生物制剂使用率为1.5%。约1/5患者住院期间进行了眼部检查,其中1/3存在葡萄膜炎,以双眼全葡萄膜炎最常见。结论新疆维吾尔自治区BS以青壮年多见,首诊科室以风湿科较多,口腔溃疡最为常见的症状,糖皮质激素及免疫抑制剂仍是BS最常用的治疗方式,生物制剂的使用率较低,葡萄膜炎为最常见的并发症。(眼科,2022,31:375-378)

Objective To summarize the clinical characteristics of Behcet's syndrome,further understand the clinical characteristics and pathogenesis in Xinjiang Uygur Autonomous Region.Design Retrospective case series.Participants 508 BS patients in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2005 to 2020.Methods The demographics and clinical data of BS patients were reviewed.Main Outcome Measures Age,gender,initial symptoms,eye lesions,medication drugs and complications.Results Among the 538 BS patients,the ratio of male to female was 1:1.96.The average age was 37.37±12.83 years,the average course of disease was 4.72±6.40 years,and the average hospital stay was 13.44±8.70 days.The first visit department was mostly rheumatology(57.0%),and oral ulcer was the most common initial symptom(69.7%)and clinical manifestation(94.1%).For medication,immunosuppressant accounted for 76.4%and thalidomide was used most frequently.Oral hormone accounted for 37.7%and the use rate of biological agents was 1.5%.About 1/5 BS patients underwent eye examination during hospitalization.1/3 patients had uveitis,and binocular uveitis was the most common type.Uveitis had more serious visual impairment and a higher hormone use rate.Conclusion Most BS in Xinjiang Uygur Autonomous Region is young and middle-aged people.The rheumatology department and is the most common first visit departments.The oral ulcer is the most common symptom.Hormones and immunosuppressants are still the most commonly used for the treatment of BS.The use rate of biological agents is low.(Ophthalmol CHN,2022,31:375-378)