过量果糖对代谢疾病影响的研究现状

Research status of the effects of excessive dietary fructose on metabolic diseases

果糖普遍用于软饮料、果汁和烘焙食品,消费量急剧增加。果糖在小肠中被吸收,在肝中被代谢,肝中刺激果糖分解、糖酵解、脂肪生成。过量的果糖与胰岛素抵抗、肝内脂质积累和高三酰甘油血症有关,高果糖的摄入导致了医疗负担的加重。本综述回顾最新的研究表明过量的果糖摄入对代谢的影响。

Objective Fructose has been widely used in soft drinks,juices and baked goods,and its consumption has increased dramatically.Fructose is absorbed in the small intestine and metabolized in the liver where it stimulates fructolysis,glycolysis,lipogenesis,and glucose production.Excessive fructose is associated with insulin resistance,intrahepatic lipid accumulation,and hypertriglyceridemia.High fructose intake causes the increase of medical burden.This review reviews recent studies showing the effects of excessive fructose intake on metabolism.