补阳还五汤治疗心脏骤停心肺复苏后脑损伤的效果

Effect on brain injury of Buyang Huanwu Decoction in the treatment of cardiopulmonary resuscitation after cardiac arrest

目的观察补阳还五汤治疗心脏骤停心肺复苏后脑损伤的效果。方法采用随机数字表法将2018年1月至2021年1月医院收治的120例心脏骤停心肺复苏后脑损伤患者分为对照组与观察组,各60例,其中观察组采用补阳还五汤+常规治疗,对照组采用常规治疗,均连续治疗28d。于治疗28d时评估两组治疗效果,比较两组治疗前、治疗28d时的神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、日常生活活动能力[Barthel指数(BI)]、认知功能[简易智力状态检查量表(MMSE)评分];治疗期间,记录两组不良反应发生情况。结果观察组治疗28d时整体治疗效果优于对照组,且治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗28d时NIHSS评分均较治疗前降低,且观察组比对照组低,两组BI、MMSE评分均较治疗前升高,且观察组比对照组高(P<0.05);治疗期间,比较两组不良反应发生率,差异无统计学意义(P>0.05)。结论心脏骤停心肺复苏后脑损伤患者采用补阳还五汤治疗效果显著、安全性好,可有效改善患者的神经功能、认知功能及日常生活活动能力。

Objective To observe the effect on brain injury of Buyang Huanwu Decoction in the treatment of cardiopulmonary resuscitation after cardiac arrest.Methods A random number table method was used to divide 120 patients with brain injury who underwent cardiopulmonary resuscitation after cardiac arrest and were treated in the hospital from January 2018 to January 2021 in⁃to control group and observation group,with 60 cases in each group,of which the observation group was treated with routine treatment+Buyang Huanwu Decoction,the control group was treated with routine treatment,both groups were treated continuously for 28 days.The therapeutic effect of the two groups was evaluated at 28 days of treatment,the neurological function[National Insti⁃tutes of Health Stroke Scale(NIHSS)score],activities of daily living[Barthel Index(BI)],cognitive function[mini mental state examination scale(MMSE)score]were compared between the two groups before and 28 days after treatment;the adverse reactions of the two groups during treatment were recorded.Results After 28 days of treatment,compared with the control group,the overall therapeutic effect was better and the total effective rate was higher in the observation group,with statistical significant differences(P<0.05);the NIHSS scores of both groups at 28 days of treatment were decreased than those before treatment,and the observation group was lower with the comparison of the control group,the scores of BI and MMSE in both groups were increased than those before treatment,and the observation group was higher with the comparison of the control group(P<0.05);during treatment,there was no statistical significant difference in the incidence of adverse reactions in both groups(P>0.05).Conclusion Buyang Huanwu decoction has significant effect and high safety in the treatment of patients with brain injury who have cardiopulmonary resuscitation after cardiac arrest,it can effectively improve neurological function,cognitive function and activities of daily living of patients.