睡眠剥夺引起血脑屏障损伤机制的研究进展

Advances in Mechanisms of Blood Brain Barrier Impairment Induced by Sleep Deprivation

睡眠剥夺是指各种原因导致的正常睡眠部分或全部缺失的过程和状态,在当前社会普遍存在,严重影响人们的身心健康并已经成为不容忽视的社会公共卫生问题。许多研究已证实,血脑屏障损伤是多种神经系统疾病的关键病理生理过程。临床和基础研究均提示睡眠剥夺可引起血脑屏障损伤,但其机制尚未完全阐明。本文总结了睡眠剥夺损伤血脑屏障机制的研究进展。

Sleep deprivation,the process and state of partial or complete lack of normal sleep caused by various factors,is prevalent at present.Seriously impairing the physical and mental health,sleep deprivation has become a public health problem that cannot be ignored.Studies have demonstrated that blood-brain barrier impairment is the key pathophysiological process of a variety of neurological diseases.Although clinical and basic studies have suggested that sleep deprivation can induce blood-brain barrier impairment,the underlying mechanisms remain to be elucidated.This review summarizes the advances in the mechanisms of blood-brain barrier impairment induced by sleep deprivation.