组织工程和3D生物打印下耳廓构建的研究进展

Research progress of tissue engineering and 3D broprinting technology in the field of auricular reconstruction

小耳畸形是我国第二多见的先天性颅面部疾病,主要表现为耳廓发育不全,部分患者同时合并外耳道狭窄或闭锁、中耳畸形。多年来,耳廓再造因其复杂性和精细性一直是整形外科面临的巨大挑战。自体肋软骨移植和Medpor支架植入是目前临床最常用的两种手术方式,但依旧存在各自的局限性。近年来,以组织工程和3D打印技术为核心的耳廓构建模式取得了一定的研究成果,给未来小耳畸形的治疗提供了新的可能。

Microtia is the second most common congenital craniofacial disease in China,mainly manifested as auricle hypoplasia,partly combined with external auditory canal stenosis or atresia,middle ear malformation.Over the years,auricle reconstruction has been a great challenge for plastic surgeons because of its complexity and precision.In ear reconstruction,autologous costal cartilage transplantation and Medpor stent implantation are the two most commonly used methods,both of which have limitations.In recent years,the auricle construction model with tissue engineering and 3D printing as the core technology has also achieved certain research results,providing new possibilities for the treatment of microtia in the future.