脂肪干细胞分泌的细胞外囊泡提高脂肪移植存活率的研究进展

Research progress of extracellular vesicles secreted by adipose-derived stem cells in improving the survival rate of fat grafting

脂肪移植已广泛应用于组织缺损、美容填充等领域,提高脂肪移植存活率是脂肪移植领域的研究热点。采用脂肪干细胞分泌的细胞外囊泡与颗粒脂肪共同移植,可提高脂肪移植的存活率。本文从细胞外囊泡的定义、分离方法、移植方法,及其在提高脂肪移植存活率中的作用等方面进行综述,总结细胞外囊泡提高脂肪移植存活率的作用机制和现有研究的不足之处,并展望后续研究的方向。

Fat grafting has been widely used in the reconstruction of tissue defects,cosmetic filling,or other fields.The improvement of survival rate is of great importance in fat grafting.Extracellular vesicles(EVs)secreted by adipose-derived stem cells improved the survival rate of fat grafting when co-transplanted with granular fat.The definition,extraction,transplantation methods of EVs,and the mechanism of EVs in improving the survival rate of fat grafting were reviewed.The shortcomings of existing studies on EVs were summarized,and the direction for future studies were also provided in this review.