跨膜蛋白97表达与肝癌患者术后复发的关系

Relationship between expression of transmembrane protein 97 and postoperative recurrence of liver cancer patients

目的探讨跨膜蛋白97(TMEM97)表达与肝癌患者术后复发的关系。方法将100例肝癌患者按照术后肿瘤是否复发分为复发组(n=37)和未复发组(n=63),检测肿瘤组织中TMEM97的表达情况,分析TMEM97与肝癌术后复发的关系。结果复发组患者TMEM97表达水平高于未复发组患者,差异有统计学意义(P﹤0.05)。Spearman相关性分析显示,TMEM97表达与肝癌术后复发呈正相关(P﹤0.05)。受试者工作特征(ROC)曲线显示,TMEM97表达预测肝癌术后复发的曲线下面积为0.808(95%CI:0.717~0.898),最佳截断值为1.770,灵敏度为0.676,特异度为0.841。多因素分析显示,低分化、TNM分期为Ⅲ期、TMEM97表达≥1.770均是肝癌术后复发的危险因素(P﹤0.05)。分化程度、TNM分期、TMEM97表达情况联合检测预测肝癌术后复发的灵敏度高于各指标单独检测,而特异度和准确度也较高,均在0.800以上。结论TMEM97在肝癌患者肿瘤组织中呈高表达,其表达水平越高术后复发风险也越高,是肝癌患者术后复发的危险因素。

Objective To investigate the relationship between the expression of transmembrane protein 97(TMEM97)and postoperative recurrence in patients with liver cancer.Method A total of 100 patients with liver cancer were divided into recurrence group(n=37)and non-recurrence group(n=63)according to whether the tumor recurred after surgery.The expression of TMEM97 in tumor tissue was detected.The correlation between TMEM97 and postoperative recurrence of liver cancer was analyzed.Result The expression level of TMEM97 in the recurrence group was higher than that in the non-recurrence group,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that the expression of TMEM97 was positively correlated with postoperative recurrence of liver cancer(P<0.05).The receiver operating characteristic(ROC)curve showed that the area under the curve of TMEM97expression for predicting postoperative recurrence of liver cancer was 0.808(95%CI:0.717-0.898),the optimal cut-off value was 1.770,the sensitivity was 0.676,and the specificity was 0.841.Multivariate analysis showed that poorly differentiated,TNM stageⅢ,and TMEM97 expression≥1.770 were risk factors for postoperative recurrence of liver cancer(P<0.05).The sensitivity of the combined detection of differentiation degree,TNM stage,and TMEM97 expression in predicting postoperative recurrence of liver cancer was higher than that of each index alone,and the specificity and accuracy were also higher,both above 0.800.Conclusion TMEM97 is up-regulation in the tumor tissue of liver cancer patients,and the higher the expression,the higher the possible risk of postoperative recurrence.This molecule could be considered as a risk factor for postoperative recurrence in patients with liver cancer.