中年与老年患者全麻诱导置入喉罩时阿芬太尼半数有效量

Median effective dose of alfentanil for laryngeal mask airway implantation during general anesthesia induction in the middle aged and elderly patients

目的研究全麻诱导靶控输注丙泊酚4.0μg/ml时,中年与老年患者置入喉罩时阿芬太尼的半数有效量(ED_(50))。方法纳入择期行下肢静脉手术及泌尿外科碎石手术的患者40例,按照年龄分为中年组(40~59岁)和老年组(60~79岁),每组20例。全麻诱导以4.0μg/ml靶控输注丙泊酚,采用改良的probit序贯法确定两组置入喉罩时阿芬太尼的ED_(50)。结果靶控输注丙泊酚4.0μg/ml时,中年组阿芬太尼的ED_(50)为13.18μg/kg(95%CI 11.80~19.87);老年组阿芬太尼的ED_(50)为10.13μg/kg(95%CI 9.10~12.19)。中年组阿芬太尼的ED_(50)高于老年组。结论靶控输注丙泊酚4.0μg/ml时,中年组阿芬太尼用于喉罩置入时的ED_(50)为13.18μg/kg,老年组的ED_(50)为10.13μg/kg。

Objective To study the median effective dose(ED_(50))of alfentanil during laryngeal mask insertion in middle-aged and elderly patients with target-controlled infusion of propofol 4.0μg/ml induced by general anesthesia.Methods Forty patients undergoing elective lower limb venous surgery and urological lithotripsy were included.They were divided into middle-aged group(40-59 years)and elderly group(60-79 years)according to their age,with 20 patients in each group.General anesthesia was induced with 4.0μg/ml target-controlled infusion of propofol,and a mod-ified probit sequential method was used to determine the ED_(50) of alfentanil for laryngeal mask insertion in both groups.Results The ED_(50) of alfentanil in the middle-aged group was 13.18μg/kg(95%CI 11.80-19.87)and 10.13μg/kg(95%CI 9.10-12.19)when target-controlled infusion of propofol was 4.0μg/ml.The ED_(50) of alfentanil was higher in the middle-aged group than in the older group.Conclusion When target-controlled infusion of propofol was 4.0μg/ml,the ED_(50) of alfentanil for laryngeal mask insertion was 13.18μg/kg in the middle-aged group and 10.13μg/kg in the elderly group.